Indiana University School of Medicine
Post-Doctoral Positions in Stem Cell Biology
Indiana University School of Medicine
We are looking for motivated and creative post-doctoral fellows to join the 3D Stem Cell Biology Research Lab (https://www.hashinolab.com) and study normal and pathological development of the human inner ear using stem cell-derived organoids as a model system (Koehler et al., Nature 2013; Liu et al., Nature Communications 2016; Koehler et al., Nature Biotechnology 2017; Tang et al., Stem Cell Reports 2019). We are studying how/when subpopulations of human otic progenitors give rise to different cell types during normal inner ear development and, using this knowledge, elucidating the mechanisms responsible for abnormal development of the inner ear in individuals with genetic mutations. We are also aiming at identifying and designing chemical compounds with the potential of promoting hair cell regeneration in the human inner ear. Applicants should have a Ph.D. degree or equivalent in biomedical sciences. The appointment is renewable annually for up to 5 years. The starting date is flexible.
The Hashino lab is a highly collaborative group of scientists with diverse research backgrounds ranging from computational biology to chemical engineering, stem cell biology and neuroscience. We conduct team-based science, while fostering independence and creative approaches to addressing fundamental scientific questions.
The experimental approaches we are currently using include: CRISPR genome editing, CUT&RUN/ChIP, scRNA-seq, live/time-lapse imaging, proteomics, synthetic biology and mathematical modeling.
If interested, please send a CV, brief description of research experience & interest and contact information of three references to: Dr. Eri Hashino (ehashino@iupui.edu), Ruth C. Holton Professor and Vice Chair for Research, Department of Otolaryngology, Indiana University School of Medicine.
Indiana University is an EEO/AA employer, M/F/D/V.
To apply for this job email your details to ehashino@iupui.edu
Charles C. Della Santina, PhD MD is a Professor of Otolaryngology – Head & Neck Surgery and Biomedical Engineering at the Johns Hopkins University School of Medicine, where he directs the Johns Hopkins Cochlear Implant Center and the Johns Hopkins Vestibular NeuroEngineering Laboratory.
Andrew Griffith received his MD and PhD in Molecular Biophysics and Biochemistry from Yale University in 1992. He completed his general surgery internship and a residency in Otolaryngology-Head and Neck Surgery at the University of Michigan in 1998. He also completed a postdoctoral research fellowship in the Department of Human Genetics as part of his training at the University of Michigan. In 1998, he joined the Division of Intramural Research (DIR) in the National Institute on Deafness and Other Communication Disorders (NIDCD). He served as a senior investigator, the chief of the Molecular Biology and Genetics Section, the chief of the Otolaryngology Branch, and the director of the DIR, as well as the deputy director for Intramural Clinical Research across the NIH Intramural Research Program. His research program identifies and characterizes molecular and cellular mechanisms of normal and disordered hearing and balance in humans and mouse models. Two primary interests of his program have been hearing loss associated with enlargement of the vestibular aqueduct, and the function of TMC genes and proteins. The latter work lead to the discovery that the deafness gene product TMC1 is a component of the hair cell sensory transduction channel. Since July of 2020, he has served as the Senior Associate Dean of Research and a Professor of Otolaryngology and Physiology in the College of Medicine at the University of Tennessee Health Science Center.
Gwenaëlle S. G. Géléoc obtained a PhD in Sensory Neurobiology from the University of Sciences in Montpellier (France) in 1996. She performed part of her PhD training at the University of Sussex, UK where she characterized sensory transduction in vestibular hair cells and a performed a comparative study between vestibular and cochlear hair cells. Gwenaelle continued her training as an electrophysiologist at University College London studying outer hair cell motility and at Harvard Medical School studying modulation of mechanotransduction in vestibular hair cells. As an independent investigator at the University of Virginia, she expanded this work and characterized the developmental acquisition of sensory transduction in mouse vestibular hair cells, the developmental acquisition of voltage-sensitive conductances in vestibular hair cells and the tonotopic gradient in the acquisition of sensory transduction in the mouse cochlea. This work along with quantitative spatio-temporal studies performed on several hair cell mechanotransduction candidates lead her to TMC1 and 2 and long-term collaborations with Andrew Griffith and Jeff Holt. Dr. Géléoc is currently Assistant Professor of Otolaryngology, at Boston Children’s Hospital where she continues to study molecular players involved in the development and function of hair cells of the inner ear and develops new therapies for the treatment of deafness and balance, with a particular focus on Usher syndrome.
Jeff Holt earned a doctorate from the Department of Physiology at the University of Rochester in 1995 for his studies of inward rectifier potassium channels in saccular hair cells. He went on to a post-doctoral position in the Neurobiology Department at Harvard Medical School and the Howard Hughes Medical Institute, where he characterized sensory transduction and adaptation in hair cells and developed a viral vector system to transfect cultured hair cells. Dr. Holt’s first faculty position was in the Neuroscience Department at the University of Virginia. In 2011 the lab moved to Boston Children’s Hospital / Harvard Medical School. Dr. Holt is currently a Professor in the Departments of Otolaryngology and Neurology in the F.M. Kirby Neurobiology Center. Dr. Holt and his team have been studying sensory transduction in auditory and vestibular hair cells over the past 20 years, with particular focus on TMC1 and TMC2 over the past 12 years. This work lead to the discovery that TMC1 forms the hair cell transduction channel. His work also focuses on development gene therapy strategies for genetic hearing loss.
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