Postdoctoral Fellowship – Inner Ear Regeneration – Harvard Medical School Massachusetts Eye & Ear Infirmary
Postdoctoral positions are available on inner ear regeneration for hearing recovery from deafness, using reprogramming, animal models, and bioengineering approach.
The focus of the project is to regenerate diverse inner ear cell types including hair cells, neurons and other cell types in adult animal models (mouse and pig) and restore hearing from deafness. We have recently uncovered a major mechanism by which adult mammalian inner ear cell types can be induced to divide and differentiate into hair cells with high efficiency by reprogramming Shu et al. Nat Common 2019). We have screened and identified drug-like molecules for adult hair cell regeneration. Using the regeneration models, we have recently identified molecules that promote ganglion neurite outgrowth, an important step to repair damaged neurons and to treat “hidden hearing loss” due to synaptopathy. The work sets a stage by which regeneration can be expanded to multiple inner ear cell types to achieve hearing restoration. We have established in vitro adult cochlea explant culture that can be used to study regeneration including screening potent compounds for regeneration. We use both mouse and large animal model (e.g. pig) and state-of-the-art approaches (reprogramming, RNA-seq, genome editing, nanoparticle delivery and physiological function study).
The positions present unique and exciting opportunities for candidate interested in using molecular, cellular, genetics, gene editing and animal models to study inner ear cell regeneration and to explore the potential for functional recovery of hearing from animal models to humans. The laboratory provides an interdisciplinary and collaborative environment in all aspects of hearing research. The laboratory is part of Eaton-Peabody Laboratories, the largest hearing research center with diverse hearing research programs. The position provides an opportunity working with industry to advance the work to human application. A successful candidate (Ph.D, M.D/Ph.D or MD) should have a strong background in the relevant areas with demonstration of track record of scientific publication.
Please email a curriculum vita, a description of research accomplishments and names of three references to:
Zheng-Yi Chen (617-909-6090)
Massachusetts Eye & Ear Infirmary/Harvard Medical School
Boston, MA 02114
To apply for this job email your details to Zheng-Yi_Chen@meei.harvard.edu