Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA. A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.
We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients. Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.
We are currently seeking a scientist with experience in genetics and molecular & cell biology to join the hearing loss team, aimed at generating novel DNA editors to solve therapeutic challenges in gene therapy for the inner ear. The scientist position is a laboratory-based appointment within the hearing loss group. The ideal candidate will have strong learning potential, including exposure to the Prime Medicine editing platform and its therapeutic application to genetic auditory diseases. Working with multidisciplinary groups, the candidate will be involved in the development of Prime Editing therapeutics to prevent hearing loss, deafness in patients.
Perform all aspects of gene editing cell-based experiments
Perform next-generation sequencing, RNAseq, RT-ddPCR
Perform cell culture experiment, including primary cells and IPSC
Perform target lead identification and optimization with a combination of molecular, cellular biology assays
Maintain accurate and detailed electronic experimental records
Communicate with and present data in a cross-functional team setting
BA/BS or Ph.D. in a relevant field (Molecular or Cell Biology, Biochemistry, or Genetics)
Experience in auditory research is preferred but not required
Proficient molecular biology skills, including primer design, cloning, PCR, qPCR, DNA, RNA isolation, next-generation sequencing required
Proficient in cell culture, including antibiotic-free maintenance, cell line generation, transfection, and transduction
Previous experience in gene editing or gene therapy is a plus
Experience with AAV vectors preferred
Ability to work both independently and in team-based environments
Detail-oriented, but can also accept and follow instructions and execute stepwise reproducible work plans
Good written, verbal communication, and organizational skills
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.
To apply for this job please visit boards.greenhouse.io.