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Charles R. “Chuck” Steele, Ph.D.

Charles R. “Chuck” Steele
August 15, 1933 – December 9, 2021

This obituary is from Stanford Press.

Charles R. “Chuck” Steele, professor emeritus of mechanical engineering and of aeronautics and astronautics, and an expert in wide-ranging scientific subjects, died Dec. 9 at the Kaiser Permanente Medical Center in Redwood City. He was 88.

Steele earned his doctorate under Professor Wilhelm Flügge in engineering mechanics – the study of the physical properties of fluids and solids – in 1960 at Stanford, where he focused on hollow shell-like structures, such as those comprising missiles and boilers. While finishing his degree, and immediately thereafter, Steele worked in industry, notably as a research scientist for Lockheed Research Laboratory in Palo Alto, where he supported the development of the Polaris missile. He also lectured at the University of California, Berkeley, before joining the Stanford faculty in the Department of Aeronautics and Astronautics in 1966. He also joined the Division of Applied Mechanics in 1971, where he was on faculty until his retirement in 2004.

Steele first gained notice at Lockheed as an expert in the study of thin-shell structures of aircraft using asymptotic analysis. Soon, however, Steele became interested in the biological implications of his research, broadening the scope of his studies to become one of the world’s leading experts in the mechanics of the cochlea, the structure of the inner ear, which turns physical energy of sound waves into electrical impulses that allow humans and most other mammals to hear.

“That leap from engineering to biology is remarkably rare professionally and, really, a reflection of who Charles was,” said Anthony Ricci, a professor of otolaryngology at Stanford School of Medicine and a frequent collaborator and co-teacher with Steele. “Biology is a lot messier than mechanics, and that uncertainty can be hard for an engineer, but not Charles. He had an intellectual fire and that carried through to the end. He was a force of nature at 80; I can’t imagine what he was like at 30.”

Steele’s first paper on the cochlea was published in 1974 and many of his subsequent works on the topic are still cited today. In fact, he remained academically active until very recently, graduating two PhDs in 2018, mentoring postdocs and publishing his last article, on the inner ear of mice, just this year.

In the late 1970s, he added another vastly different discipline to his repertoire, developing ways to non-invasively measure bone strength to diagnose osteoporosis. Then, in the 1990s, he layered on yet another, researching the mechanics of plant growth.

In total, it is estimated Steele published some 100 journal articles, five review articles and numerous abstracts in conference proceedings, while delivering guest lectures around the world. As an editor, he was perhaps even more influential, becoming editor-in-chief of the International Journal of Solids and Structures, one of the foremost journals in applied mechanics, in 1985. His second wife, Marie-Louise Steele, who died in 2009, worked closely with him on the journal and was instrumental in making it highly successful.

As teacher, Steele was similarly admired. He taught plates and the aforementioned shell structures, differential geometry and the mechanics of hearing to graduate students, and statics, dynamics and mechanics of materials to undergrads. He mentored more than 70 doctoral students through their dissertations and maintained contact with many of them throughout their careers.

“I was not his student, but I learned a lot from Charles in the 20 years we worked together,” recalled one-time Stanford colleague Sunil Puria, who is now at Harvard University. “He was my primary collaborator, but really he mentored all of us. Just this year, we collaborated on a paper. He provided constructive feedback only a few weeks ago. Amazing! He gives us hope as we ourselves get older, that we can do good science late into life. He was a gentle soul and I miss his calm demeanor.”

Professional recognition followed these accomplishments. He was elected a fellow of American Society of Mechanical Engineers in 1980 and the American Academy of Mechanics in 1985. In 1995, he became a member of the the National Academy of Engineering. In 1988, the National Institutes of Health bestowed the Claude Pepper Award upon Steele for his work in hearing.

“He was highly regarded in four different disciplines. How many researchers can say that? When you add in his influence as a mentor and editor, his career stands out,” said longtime friend and fellow Stanford Professor Emeritus George Springer. “But beside that, he was just the nicest person you can imagine. I will miss him. Stanford will miss him.”

Steele’s personal interests were also wide-ranging. He was invited to try out for the varsity basketball team at Texas A&M, though he declined to focus on his studies, and was known to love a Stanford football game. He was an avid birder, as well. He also loved opera and played French horn with the Peninsula Symphony for decades.

Charles Richard Steele was born August 15, 1933, in Royal, Iowa, to Edwin and Ruth Steele, but grew up in Fort Worth, Texas. He earned his Bachelor of Science degree in mechanical engineering from Texas A&M University in 1956 and his PhD from Stanford in 1960.

He is survived by wife Kelly Zhang Steele and stepchildren Jackson Wen of Menlo Park, and Alexandra Lu of Berkeley. He survived his first wife, Gail Steele, who died in 1970, and second wife, Marie-Louise Steele, who died in 2009. Steele is also survived by his son Eric Steele and wife Turian (Theresa) Steele and their children Wanittha (Oum) Thapanakul, Kritsada (Ed) Thapanakul and Piyada (Ann) Thapanakul of Seattle; son Brett Steele and wife Tamera Dorland of Alexandria, Virginia, and their children Ian Williams of Washington, D.C., and Elizabeth Williams of Canberra, Australia; son Jay Steele and wife Ilze Steele of Milpitas, and daughters Julia Steele of Santa Cruz, and Jessica Steele of Milpitas; and son Ryan Steele and wife Andrea Steele and children Carmen, Gaby and Alex Steele of San Francisco.

A memorial service at Stanford will be held in early February. Location and exact time are to be determined. In lieu of flowers, donations in the name of Charles Richard Steele can be made to Stanford University in his honor.

 

Memorial Video made by his wife Kelly Zhang Steele: https://wx.xiaoniangao.cn/share/album.html?lid=UANk.EAUwD9.DAbN&fr_om=app

Donations in his honor: https://give.stanford.edu/school-engineering/?kwoDCPreselect=KDC-3HY2WG5

Hearing loss can significantly disrupt the ability of children to become mainstreamed in educational environments that emphasize spoken language as a primary means of communication. Similarly, adults who lose their hearing after communicating using spoken language have numerous challenges understanding speech and integrating into social situations. These challenges are particularly significant in noisy situations, where multiple sound sources often arrive at the ears from various directions. Intervention with hearing aids and/or cochlear implants (CIs) has proven to be highly successful for restoring some aspects of communication, including speech understanding and language acquisition. However, there is also typically a notable gap in outcomes relative to normal-hearing listeners. Importantly, auditory abilities operate in the context of how hearing integrates with other senses. Notably, the visual system is tightly couples to the auditory system. Vision is known to impact auditory perception and neural mechanisms in vision and audition are tightly coupled, thus, in order to understand how we hear and how CIs affect auditory perception we must consider the integrative effects across these senses.

We start with Rebecca Alexander, a compelling public speaker who has been living with Usher’s Syndrome, a genetic disorder found in tens of thousands of people, causing both deafness and blindness in humans. Ms. Alexander will be introduced by Dr. Jeffrey Holt, who studies gene therapy strategies for hearing restoration. The symposium then highlights the work of scientists working across these areas. Here we integrate psychophysics, clinical research, and biological approaches, aiming to gain a coherent understanding of how we might ultimately improve outcomes in patients. Drs. Susana Martinez-Conde and Stephen Macknik are new to the ARO community, and will discuss neurobiology of the visual system as it relates to visual prostheses. Dr. Jennifer Groh’s work will then discuss multi-sensory processing and how it is that vision helps us hear. Having set the stage for thinking about the role of vision in a multisensory auditory world, we will hear from experts in the area of cochlear implants. Dr. René H Gifford will discuss recent work on electric-acoustic integration in children and adults, and Dr. Sharon Cushing will discuss her work as a clinician on 3-D auditory and vestibular effects. Dr. Matthew Winn will talk about cognitive load and listening effort using pupillometry, and we will end with Dr. Rob Shepherd’s discussion of current work and future possibilities involving biological treatments and neural prostheses. Together, these presentations are designed to provide a broad and interdisciplinary view of the impact of sensory restoration in hearing, vision and balance, and the potential for future approaches for improving the lives of patients.

Kirupa Suthakar, PhD - Dr Kirupa Suthakar is a postdoctoral fellow at NIH/NIDCD, having formerly trained as a postdoctoral fellow at Massachusetts Eye and Ear/Harvard Medical School and doctoral student at Garvan Institute of Medical Research/UNSW Australia.  Kirupa's interest in the mind and particular fascination by how we are able to perceive the world around us led her to pursue a research career in auditory neuroscience.  To date, Kirupa's research has broadly focused on neurons within the auditory efferent circuit, which allow the brain to modulate incoming sound signals at the ear.  Kirupa is active member of the spARO community, serving as the Chair Elect for 2021.

 

 

I began studying the vestibular system during my dissertation research at the Università di Pavia with Professors Ivo Prigioni and GianCarlo Russo. I had two postdoctoral fellowships, first at the University of Rochester with Professor Christopher Holt and then at the University of Illinois at Chicago with Professors Jonathan Art and Jay Goldberg.

My research focuses on characterizing the biophysics of synaptic transmission between hair cells and primary afferents in the vestibular system. For many years an outstanding question in vestibular physiology was how the transduction current in the type I hair cell was sufficient, in the face of large conductances on at rest, to depolarize it to potentials necessary for conventional synaptic transmission with its unique afferent calyx.

In collaboration with Dr. Art, I overcame the technical challenges of simultaneously recording from type I hair cells and their enveloping calyx afferent to investigate this question. I was able to show that with depolarization of either hair cell or afferent, potassium ions accumulating in the cleft depolarize the synaptic partner. Conclusions from these studies are that due to the extended apposition between type I hair cell and its afferent, there are three modes of communication across the synapse. The slowest mode of transmission reflects the dynamic changes in potassium ion concentration in the cleft which follow the integral of the ongoing hair cell transduction current. The intermediate mode of transmission is indirectly a result of this potassium elevation which serves as the mechanism by which the hair cell potential is depolarized to levels necessary for calcium influx and the vesicle fusion typical of glutamatergic quanta. This increase in potassium concentration also depolarizes the afferent to potentials that allow the quantal EPSPs to trigger action potentials. The third and most rapid mode of transmission like the slow mode of transmission is bidirectional, and a current flowing out of either hair cell or afferent into the synaptic cleft will divide between a fraction flowing out into the bath, and a fraction flowing across the cleft into its synaptic partner.

The technical achievement of the dual electrode approach has enabled us to identify new facets of vestibular end organ synaptic physiology that in turn raise new questions and challenges for our field. I look forward with great excitement to the next chapter in my scientific story.

 

Charles C. Della Santina, PhD MD is a Professor of Otolaryngology – Head & Neck Surgery and Biomedical Engineering at the Johns Hopkins University School of Medicine, where he directs the Johns Hopkins Cochlear Implant Center and the Johns Hopkins Vestibular NeuroEngineering Laboratory.

As a practicing neurotologic surgeon, Dr. Della Santina specializes in treatment of middle ear, inner ear and auditory/vestibular nerve disorders. His clinical interests include restoration of hearing via cochlear implantation and management of patients who suffer from vestibular disorders, with a particular focus on helping individuals disabled by chronic postural instability and unsteady vision after bilateral loss of vestibular sensation. His laboratory’s research centers on basic and applied research supporting development of vestibular implants, which are medical devices intended to partially restore inner ear sensation of head movement. In addition to that work, his >90 publications include studies characterizing inner ear physiology and anatomy; describing novel clinical tests of vestibular function; and clarifying the effects of cochlear implantation, vestibular implantation, superior canal dehiscence syndrome and intratympanic gentamicin therapy on the inner ear and central nervous system.  Dr. Della Santina is also the founder and CEO/Chief Scientific Officer of Labyrinth Devices LLC, a company dedicated to bringing novel vestibular testing and implant technology into routine clinical care.

Andrew Griffith received his MD and PhD in Molecular Biophysics and Biochemistry from Yale University in 1992. He completed his general surgery internship and a residency in Otolaryngology-Head and Neck Surgery at the University of Michigan in 1998. He also completed a postdoctoral research fellowship in the Department of Human Genetics as part of his training at the University of Michigan. In 1998, he joined the Division of Intramural Research (DIR) in the National Institute on Deafness and Other Communication Disorders (NIDCD). He served as a senior investigator, the chief of the Molecular Biology and Genetics Section, the chief of the Otolaryngology Branch, and the director of the DIR, as well as the deputy director for Intramural Clinical Research across the NIH Intramural Research Program. His research program identifies and characterizes molecular and cellular mechanisms of normal and disordered hearing and balance in humans and mouse models. Two primary interests of his program have been hearing loss associated with enlargement of the vestibular aqueduct, and the function of TMC genes and proteins. The latter work lead to the discovery that the deafness gene product TMC1 is a component of the hair cell sensory transduction channel. Since July of 2020, he has served as the Senior Associate Dean of Research and a Professor of Otolaryngology and Physiology in the College of Medicine at the University of Tennessee Health Science Center.

Gwenaëlle S. G. Géléoc obtained a PhD in Sensory Neurobiology from the University of Sciences in Montpellier (France) in 1996. She performed part of her PhD training at the University of Sussex, UK where she characterized sensory transduction in vestibular hair cells and a performed a comparative study between vestibular and cochlear hair cells. Gwenaelle continued her training as an electrophysiologist at University College London studying outer hair cell motility and at Harvard Medical School studying modulation of mechanotransduction in vestibular hair cells. As an independent investigator at the University of Virginia, she expanded this work and characterized the developmental acquisition of sensory transduction in mouse vestibular hair cells, the developmental acquisition of voltage-sensitive conductances in vestibular hair cells and the tonotopic gradient in the acquisition of sensory transduction in the mouse cochlea. This work along with quantitative spatio-temporal studies performed on several hair cell mechanotransduction candidates lead her to TMC1 and 2 and long-term collaborations with Andrew Griffith and Jeff Holt. Dr. Géléoc is currently Assistant Professor of Otolaryngology, at Boston Children’s Hospital where she continues to study molecular players involved in the development and function of hair cells of the inner ear and develops new therapies for the treatment of deafness and balance, with a particular focus on Usher syndrome.

Jeff Holt earned a doctorate from the Department of Physiology at the University of Rochester in 1995 for his studies of inward rectifier potassium channels in saccular hair cells.  He went on to a post-doctoral position in the Neurobiology Department at Harvard Medical School and the Howard Hughes Medical Institute, where he characterized sensory transduction and adaptation in hair cells and developed a viral vector system to transfect cultured hair cells.  Dr. Holt’s first faculty position was in the Neuroscience Department at the University of Virginia.  In 2011 the lab moved to Boston Children’s Hospital / Harvard Medical School.  Dr. Holt is currently a Professor in the Departments of Otolaryngology and Neurology in the F.M. Kirby Neurobiology Center.  Dr. Holt and his team have been studying sensory transduction in auditory and vestibular hair cells over the past 20 years, with particular focus on TMC1 and TMC2 over the past 12 years.  This work lead to the discovery that TMC1 forms the hair cell transduction channel.  His work also focuses on development gene therapy strategies for genetic hearing loss.