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Ruediger (Ruedi) Thalmann, MD

ARO Award of Merit, 1996

You cannot go wrong when you are born in Paris”


Dr. Ruediger (Ruedi) Thalmann passed away Saturday, August 25, 2018 with his wife of 51 years and fellow ARO member, Dr. Isolde (Ici) Thalmann, by his side.  We have lost a remarkable scientist, an enthusiastic collaborator and wonderful colleague.  Ruedi joined the Department of Otolaryngology at Washington University School of Medicine in 1963.  He remained an extremely active faculty member, becoming Professor Emeritus of Otolaryngology and Lecturer in 1992.  He retired from his work at Washington University at the age of 82.   Over the years he has carried out research (basic and clinically-oriented) on the auditory and vestibular system, ranging from human to zebrafish. His research was almost exclusively NIH-supported, where he functioned in practically every position, from PI to Co-I to collaborator to consultant, to member of the Study Section.  Through his contribution to ear research, he was honored with the Award of Merit from the Association for Research in Otolaryngology in 1996.  Dr. Thalmann was a member of the prestigious Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum.

Modified from the Department of Otolarynology, Washington University, 9/6/2018. 

Ruediger’s motto always was ‘I do it my way’ and he died on his own terms, surrounded by his wife Ici, a circle of dear friends, and his dog Manuela. Ruediger was born in Paris, and he always said that ‘you cannot go wrong when you are born in Paris’. This did not always come true. During World War II, as a teenager, he had to leave a very happy and comfortable life, having grown up in Marburg, Slovenia and, as an Austrian citizen, resettled in Styria, Austria. He followed in the footsteps of his grandfather, a surgeon, and his father, an otolaryngologist, studied medicine in Graz and Vienna and became a board-certified otolaryngologist. His keen intellect, curiosity and ambition lead him to emigrate to the United States. He became a faculty member at Washington University in St. Louis, Missouri. There he met his wife Isolde, and together they became internationally known pioneers of cochlear and vestibular biochemistry. While Isolde retired at age 65 and followed her passion – dancing – and built the Dancing in the Desert Studio in Abiquiu, New Mexico, Ruediger continued his research at Washington University, changing his field from auditory biochemistry to vestibular biophysics. At age 85, arguably the oldest researcher who worked under the auspices of an NIH grant, he decided to retire. Ruediger touched many lives as a mentor to fellows from every continent.  He was a unique man, a quintessential Renaissance man. He took part in the van Cliburn ‘Outstanding Amateur Pianist Competition’, and Ballroom dance competitions; his home became the gathering place for artists; music lovers enjoyed many ‘Hauskonzerts’ by renowned musicians; he was an avid and knowledgeable art collector. He also had a strong social conscience, and a commitment to help others through action and philanthropy. As he requested, a private service to celebrate his life (of course with music) was held in December of 2018 with the renowned Arianna String Quartet playing Schubert’s “Death and the Maiden” quartet.

Isolde Thalmann’s contact information:


I began studying the vestibular system during my dissertation research at the Università di Pavia with Professors Ivo Prigioni and GianCarlo Russo. I had two postdoctoral fellowships, first at the University of Rochester with Professor Christopher Holt and then at the University of Illinois at Chicago with Professors Jonathan Art and Jay Goldberg.

My research focuses on characterizing the biophysics of synaptic transmission between hair cells and primary afferents in the vestibular system. For many years an outstanding question in vestibular physiology was how the transduction current in the type I hair cell was sufficient, in the face of large conductances on at rest, to depolarize it to potentials necessary for conventional synaptic transmission with its unique afferent calyx.

In collaboration with Dr. Art, I overcame the technical challenges of simultaneously recording from type I hair cells and their enveloping calyx afferent to investigate this question. I was able to show that with depolarization of either hair cell or afferent, potassium ions accumulating in the cleft depolarize the synaptic partner. Conclusions from these studies are that due to the extended apposition between type I hair cell and its afferent, there are three modes of communication across the synapse. The slowest mode of transmission reflects the dynamic changes in potassium ion concentration in the cleft which follow the integral of the ongoing hair cell transduction current. The intermediate mode of transmission is indirectly a result of this potassium elevation which serves as the mechanism by which the hair cell potential is depolarized to levels necessary for calcium influx and the vesicle fusion typical of glutamatergic quanta. This increase in potassium concentration also depolarizes the afferent to potentials that allow the quantal EPSPs to trigger action potentials. The third and most rapid mode of transmission like the slow mode of transmission is bidirectional, and a current flowing out of either hair cell or afferent into the synaptic cleft will divide between a fraction flowing out into the bath, and a fraction flowing across the cleft into its synaptic partner.

The technical achievement of the dual electrode approach has enabled us to identify new facets of vestibular end organ synaptic physiology that in turn raise new questions and challenges for our field. I look forward with great excitement to the next chapter in my scientific story.


Charles C. Della Santina, PhD MD is a Professor of Otolaryngology – Head & Neck Surgery and Biomedical Engineering at the Johns Hopkins University School of Medicine, where he directs the Johns Hopkins Cochlear Implant Center and the Johns Hopkins Vestibular NeuroEngineering Laboratory.

As a practicing neurotologic surgeon, Dr. Della Santina specializes in treatment of middle ear, inner ear and auditory/vestibular nerve disorders. His clinical interests include restoration of hearing via cochlear implantation and management of patients who suffer from vestibular disorders, with a particular focus on helping individuals disabled by chronic postural instability and unsteady vision after bilateral loss of vestibular sensation. His laboratory’s research centers on basic and applied research supporting development of vestibular implants, which are medical devices intended to partially restore inner ear sensation of head movement. In addition to that work, his >90 publications include studies characterizing inner ear physiology and anatomy; describing novel clinical tests of vestibular function; and clarifying the effects of cochlear implantation, vestibular implantation, superior canal dehiscence syndrome and intratympanic gentamicin therapy on the inner ear and central nervous system.  Dr. Della Santina is also the founder and CEO/Chief Scientific Officer of Labyrinth Devices LLC, a company dedicated to bringing novel vestibular testing and implant technology into routine clinical care.

Andrew Griffith received his MD and PhD in Molecular Biophysics and Biochemistry from Yale University in 1992. He completed his general surgery internship and a residency in Otolaryngology-Head and Neck Surgery at the University of Michigan in 1998. He also completed a postdoctoral research fellowship in the Department of Human Genetics as part of his training at the University of Michigan. In 1998, he joined the Division of Intramural Research (DIR) in the National Institute on Deafness and Other Communication Disorders (NIDCD). He served as a senior investigator, the chief of the Molecular Biology and Genetics Section, the chief of the Otolaryngology Branch, and the director of the DIR, as well as the deputy director for Intramural Clinical Research across the NIH Intramural Research Program. His research program identifies and characterizes molecular and cellular mechanisms of normal and disordered hearing and balance in humans and mouse models. Two primary interests of his program have been hearing loss associated with enlargement of the vestibular aqueduct, and the function of TMC genes and proteins. The latter work lead to the discovery that the deafness gene product TMC1 is a component of the hair cell sensory transduction channel. Since July of 2020, he has served as the Senior Associate Dean of Research and a Professor of Otolaryngology and Physiology in the College of Medicine at the University of Tennessee Health Science Center.

Gwenaëlle S. G. Géléoc obtained a PhD in Sensory Neurobiology from the University of Sciences in Montpellier (France) in 1996. She performed part of her PhD training at the University of Sussex, UK where she characterized sensory transduction in vestibular hair cells and a performed a comparative study between vestibular and cochlear hair cells. Gwenaelle continued her training as an electrophysiologist at University College London studying outer hair cell motility and at Harvard Medical School studying modulation of mechanotransduction in vestibular hair cells. As an independent investigator at the University of Virginia, she expanded this work and characterized the developmental acquisition of sensory transduction in mouse vestibular hair cells, the developmental acquisition of voltage-sensitive conductances in vestibular hair cells and the tonotopic gradient in the acquisition of sensory transduction in the mouse cochlea. This work along with quantitative spatio-temporal studies performed on several hair cell mechanotransduction candidates lead her to TMC1 and 2 and long-term collaborations with Andrew Griffith and Jeff Holt. Dr. Géléoc is currently Assistant Professor of Otolaryngology, at Boston Children’s Hospital where she continues to study molecular players involved in the development and function of hair cells of the inner ear and develops new therapies for the treatment of deafness and balance, with a particular focus on Usher syndrome.

Jeff Holt earned a doctorate from the Department of Physiology at the University of Rochester in 1995 for his studies of inward rectifier potassium channels in saccular hair cells.  He went on to a post-doctoral position in the Neurobiology Department at Harvard Medical School and the Howard Hughes Medical Institute, where he characterized sensory transduction and adaptation in hair cells and developed a viral vector system to transfect cultured hair cells.  Dr. Holt’s first faculty position was in the Neuroscience Department at the University of Virginia.  In 2011 the lab moved to Boston Children’s Hospital / Harvard Medical School.  Dr. Holt is currently a Professor in the Departments of Otolaryngology and Neurology in the F.M. Kirby Neurobiology Center.  Dr. Holt and his team have been studying sensory transduction in auditory and vestibular hair cells over the past 20 years, with particular focus on TMC1 and TMC2 over the past 12 years.  This work lead to the discovery that TMC1 forms the hair cell transduction channel.  His work also focuses on development gene therapy strategies for genetic hearing loss.