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EARssentials- Concepts and Techniques of Contemporary Hearing Research (July 18-22, 2022)

 

Molecular Neuroscience: Focus on Sensory Disorders Miami Winter Symposium 2023

Conference title:
Molecular Neuroscience: Focus on Sensory Disorders
Miami Winter Symposium 2023

 Dates:  January 30 – February 1, 2023

Location:  Miami, FL, USA

 Website:  http://www.miamiwintersymposium.com

Secretariat:  Gemma Boodell, Elsevier, The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, UK

Email: g.boodell@elsevier.com

Short announcement / Synopsis:  The Miami Winter Symposium 2023 is dedicated to Molecular Neuroscience: Focus on Sensory Disorders and includes an international line-up of renowned speakers – selected to provide attendees with a unique opportunity to meet with and hear from representatives from leading research centers on basic research, translational issues, and potential or actual clinical applications in sensory neuroscience.

Abstracts are invited for short Spotlight Talks and Posters on the conference topics - hearing, vision, smell, taste and pain/itch/touch – by September 16, 2022 to supplement the invited plenary program.

7th World Congress of Cochlear Implantation in Emerging Countries in Istanbul, Turkey - 14-16 September 2023

7th World Congress of Cochlear Implantation in Emerging Countries in Istanbul, Turkey between 14-16 September 2023

 

Dear Colleagues,

As Hacettepe Implant team, we are pleased to announce that we are organizing the 7th World Congress of Cochlear Implantation in Emerging Countries in Istanbul, Turkey between 14-16 September 2023.

This meeting series was started in 2016 by Professor Muaz Tarabichi who set up the organization Global Cochlear Implant Access Network. The aim of these meetings is to find solutions to challenges in the field of implantation in emerging nations.

The meeting was used to be held every year until 2019 but because of Covid19 Pandemic, it was not possible to perform this face-to-face in India which was done as an online meeting in 2021. Now with the gradual control of the Covid 19 pandemic, we plan to perform the meeting face-to-face between 14-16 September 2023 in Istanbul, Turkey.

The reason we prefer to make the meeting in Istanbul is that there are direct flights from many countries all over the world enabling many people to travel without connecting flights. In addition, being the capital of three empires in the past, Istanbul offers a rich history, as well as being a picturesque city.

It is also the meeting point of east and west where the experience of the developed world will be shared with emerging nations. We have set the congress date as September because this month in Turkey is quite warm and offers very good opportunities for outside activities while enjoying the beautiful city.

We plan to make the meeting in 3 halls. We are developing guidelines for cochlear implantation and these will be presented during the meeting. We will also have interesting case presentations, new developments and oral presentations along with satellite symposiums of companies.

Let us meet in 14-16 September 2023 in Istanbul: the meeting point of east and west.

 

Sincerely yours,

Professor Levent Sennaroglu M.D.

President of the 7th World Congress of Cochlear Implantation in Emerging Countries,

Department of Otolaryngology,

Hacettepe University Medical Faculty

Ankara, Turkey

 

 

1st Annual Texas Auditory and Vestibular Research Conference

1st Annual Texas Auditory and Vestibular Research Conference

Peripheral-Central Interactions in the Auditory and Vestibular System

October 6-7, 2022 in Houston, TX

Check out their website here- texasavrc.rice.edu

The conference encompasses synaptic transmission, ion channel electrophysiology, neural circuitry, cell biology, molecular genetics and computational neuroscience. Understanding peripheral-central interactions is necessary for the design of cochlear and vestibular implants.

Confirmed Keynote Speakers:

Catherine Weisz, Acting Chief, Section on Neuronal Circuitry, NIH National Institute on Deafness and Other Communication Disorders

Daniel Polley, Director of the Lauer Tinnitus Research Center, Mass Eye and Ear, Harvard University

Meeting Highlights:

Conference will include opportunity for posters from submitted abstracts as well as a discussion on diversity, equity, and inclusion in auditory and vestibular research.

Hosted by Rice University and Baylor College of Medicine in Houston, TX

 

Hearing loss can significantly disrupt the ability of children to become mainstreamed in educational environments that emphasize spoken language as a primary means of communication. Similarly, adults who lose their hearing after communicating using spoken language have numerous challenges understanding speech and integrating into social situations. These challenges are particularly significant in noisy situations, where multiple sound sources often arrive at the ears from various directions. Intervention with hearing aids and/or cochlear implants (CIs) has proven to be highly successful for restoring some aspects of communication, including speech understanding and language acquisition. However, there is also typically a notable gap in outcomes relative to normal-hearing listeners. Importantly, auditory abilities operate in the context of how hearing integrates with other senses. Notably, the visual system is tightly couples to the auditory system. Vision is known to impact auditory perception and neural mechanisms in vision and audition are tightly coupled, thus, in order to understand how we hear and how CIs affect auditory perception we must consider the integrative effects across these senses.

We start with Rebecca Alexander, a compelling public speaker who has been living with Usher’s Syndrome, a genetic disorder found in tens of thousands of people, causing both deafness and blindness in humans. Ms. Alexander will be introduced by Dr. Jeffrey Holt, who studies gene therapy strategies for hearing restoration. The symposium then highlights the work of scientists working across these areas. Here we integrate psychophysics, clinical research, and biological approaches, aiming to gain a coherent understanding of how we might ultimately improve outcomes in patients. Drs. Susana Martinez-Conde and Stephen Macknik are new to the ARO community, and will discuss neurobiology of the visual system as it relates to visual prostheses. Dr. Jennifer Groh’s work will then discuss multi-sensory processing and how it is that vision helps us hear. Having set the stage for thinking about the role of vision in a multisensory auditory world, we will hear from experts in the area of cochlear implants. Dr. René H Gifford will discuss recent work on electric-acoustic integration in children and adults, and Dr. Sharon Cushing will discuss her work as a clinician on 3-D auditory and vestibular effects. Dr. Matthew Winn will talk about cognitive load and listening effort using pupillometry, and we will end with Dr. Rob Shepherd’s discussion of current work and future possibilities involving biological treatments and neural prostheses. Together, these presentations are designed to provide a broad and interdisciplinary view of the impact of sensory restoration in hearing, vision and balance, and the potential for future approaches for improving the lives of patients.

Kirupa Suthakar, PhD - Dr Kirupa Suthakar is a postdoctoral fellow at NIH/NIDCD, having formerly trained as a postdoctoral fellow at Massachusetts Eye and Ear/Harvard Medical School and doctoral student at Garvan Institute of Medical Research/UNSW Australia.  Kirupa's interest in the mind and particular fascination by how we are able to perceive the world around us led her to pursue a research career in auditory neuroscience.  To date, Kirupa's research has broadly focused on neurons within the auditory efferent circuit, which allow the brain to modulate incoming sound signals at the ear.  Kirupa is active member of the spARO community, serving as the Chair Elect for 2021.

 

 

I began studying the vestibular system during my dissertation research at the Università di Pavia with Professors Ivo Prigioni and GianCarlo Russo. I had two postdoctoral fellowships, first at the University of Rochester with Professor Christopher Holt and then at the University of Illinois at Chicago with Professors Jonathan Art and Jay Goldberg.

My research focuses on characterizing the biophysics of synaptic transmission between hair cells and primary afferents in the vestibular system. For many years an outstanding question in vestibular physiology was how the transduction current in the type I hair cell was sufficient, in the face of large conductances on at rest, to depolarize it to potentials necessary for conventional synaptic transmission with its unique afferent calyx.

In collaboration with Dr. Art, I overcame the technical challenges of simultaneously recording from type I hair cells and their enveloping calyx afferent to investigate this question. I was able to show that with depolarization of either hair cell or afferent, potassium ions accumulating in the cleft depolarize the synaptic partner. Conclusions from these studies are that due to the extended apposition between type I hair cell and its afferent, there are three modes of communication across the synapse. The slowest mode of transmission reflects the dynamic changes in potassium ion concentration in the cleft which follow the integral of the ongoing hair cell transduction current. The intermediate mode of transmission is indirectly a result of this potassium elevation which serves as the mechanism by which the hair cell potential is depolarized to levels necessary for calcium influx and the vesicle fusion typical of glutamatergic quanta. This increase in potassium concentration also depolarizes the afferent to potentials that allow the quantal EPSPs to trigger action potentials. The third and most rapid mode of transmission like the slow mode of transmission is bidirectional, and a current flowing out of either hair cell or afferent into the synaptic cleft will divide between a fraction flowing out into the bath, and a fraction flowing across the cleft into its synaptic partner.

The technical achievement of the dual electrode approach has enabled us to identify new facets of vestibular end organ synaptic physiology that in turn raise new questions and challenges for our field. I look forward with great excitement to the next chapter in my scientific story.

 

Charles C. Della Santina, PhD MD is a Professor of Otolaryngology – Head & Neck Surgery and Biomedical Engineering at the Johns Hopkins University School of Medicine, where he directs the Johns Hopkins Cochlear Implant Center and the Johns Hopkins Vestibular NeuroEngineering Laboratory.

As a practicing neurotologic surgeon, Dr. Della Santina specializes in treatment of middle ear, inner ear and auditory/vestibular nerve disorders. His clinical interests include restoration of hearing via cochlear implantation and management of patients who suffer from vestibular disorders, with a particular focus on helping individuals disabled by chronic postural instability and unsteady vision after bilateral loss of vestibular sensation. His laboratory’s research centers on basic and applied research supporting development of vestibular implants, which are medical devices intended to partially restore inner ear sensation of head movement. In addition to that work, his >90 publications include studies characterizing inner ear physiology and anatomy; describing novel clinical tests of vestibular function; and clarifying the effects of cochlear implantation, vestibular implantation, superior canal dehiscence syndrome and intratympanic gentamicin therapy on the inner ear and central nervous system.  Dr. Della Santina is also the founder and CEO/Chief Scientific Officer of Labyrinth Devices LLC, a company dedicated to bringing novel vestibular testing and implant technology into routine clinical care.

Andrew Griffith received his MD and PhD in Molecular Biophysics and Biochemistry from Yale University in 1992. He completed his general surgery internship and a residency in Otolaryngology-Head and Neck Surgery at the University of Michigan in 1998. He also completed a postdoctoral research fellowship in the Department of Human Genetics as part of his training at the University of Michigan. In 1998, he joined the Division of Intramural Research (DIR) in the National Institute on Deafness and Other Communication Disorders (NIDCD). He served as a senior investigator, the chief of the Molecular Biology and Genetics Section, the chief of the Otolaryngology Branch, and the director of the DIR, as well as the deputy director for Intramural Clinical Research across the NIH Intramural Research Program. His research program identifies and characterizes molecular and cellular mechanisms of normal and disordered hearing and balance in humans and mouse models. Two primary interests of his program have been hearing loss associated with enlargement of the vestibular aqueduct, and the function of TMC genes and proteins. The latter work lead to the discovery that the deafness gene product TMC1 is a component of the hair cell sensory transduction channel. Since July of 2020, he has served as the Senior Associate Dean of Research and a Professor of Otolaryngology and Physiology in the College of Medicine at the University of Tennessee Health Science Center.

Gwenaëlle S. G. Géléoc obtained a PhD in Sensory Neurobiology from the University of Sciences in Montpellier (France) in 1996. She performed part of her PhD training at the University of Sussex, UK where she characterized sensory transduction in vestibular hair cells and a performed a comparative study between vestibular and cochlear hair cells. Gwenaelle continued her training as an electrophysiologist at University College London studying outer hair cell motility and at Harvard Medical School studying modulation of mechanotransduction in vestibular hair cells. As an independent investigator at the University of Virginia, she expanded this work and characterized the developmental acquisition of sensory transduction in mouse vestibular hair cells, the developmental acquisition of voltage-sensitive conductances in vestibular hair cells and the tonotopic gradient in the acquisition of sensory transduction in the mouse cochlea. This work along with quantitative spatio-temporal studies performed on several hair cell mechanotransduction candidates lead her to TMC1 and 2 and long-term collaborations with Andrew Griffith and Jeff Holt. Dr. Géléoc is currently Assistant Professor of Otolaryngology, at Boston Children’s Hospital where she continues to study molecular players involved in the development and function of hair cells of the inner ear and develops new therapies for the treatment of deafness and balance, with a particular focus on Usher syndrome.

Jeff Holt earned a doctorate from the Department of Physiology at the University of Rochester in 1995 for his studies of inward rectifier potassium channels in saccular hair cells.  He went on to a post-doctoral position in the Neurobiology Department at Harvard Medical School and the Howard Hughes Medical Institute, where he characterized sensory transduction and adaptation in hair cells and developed a viral vector system to transfect cultured hair cells.  Dr. Holt’s first faculty position was in the Neuroscience Department at the University of Virginia.  In 2011 the lab moved to Boston Children’s Hospital / Harvard Medical School.  Dr. Holt is currently a Professor in the Departments of Otolaryngology and Neurology in the F.M. Kirby Neurobiology Center.  Dr. Holt and his team have been studying sensory transduction in auditory and vestibular hair cells over the past 20 years, with particular focus on TMC1 and TMC2 over the past 12 years.  This work lead to the discovery that TMC1 forms the hair cell transduction channel.  His work also focuses on development gene therapy strategies for genetic hearing loss.​